Quinolines and derivatives
TARGETMOL CHEMICALS INC GANDOTINIB 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50 3 nM) effective in JAK2V617F(Ki 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3. purity: 99%
Medchemexpress LLC MSA-2 | 129425-81-6 | 99.8% | 294.32 | 200 MG
MSA-2 is a potent and orally available non-nucleotide STING agonist that binds to STING as a noncovalent dimer with nanomolar affinity. It stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.
- Potent and orally available non-nucleotide STING agonist
- Binds to STING as a noncovalent dimer with nanomolar affinity
- Stimulates interferon-β secretion in tumors
- Induces tumor regression with durable antitumor immunity
- Synergizes with anti-PD-1 in syngeneic mouse tumor models
- Achieves comparable exposure in tumor and plasma
- Exhibits dose-dependent antitumor activity
- Induces elevations of IFN-β, IL-6, and TNF-α in tumors
Apexbio Technology LLC Rosiglitazone(Synonyms: Avandia, BRL-49653, Rosiglitazone Maleate, Rosiglitazone Base, BRL49653C, RGZ, Rosiglizole), 200mg, CAS: 122320-73-4.
Rosiglitazone (CAS 122320-73-4) is a synthetic thiazolidinedione (TZD) that functions as an agonist of peroxisome proliferator-activated receptor gamma (PPAR ) a nuclear receptor highly expressed in adipose tissues Upon ligand binding PPAR forms heterodimers with retinoid X receptors promoting transcriptional activation of genes regulating adipogenesis glucose uptake lipid metabolism and insulin sensitivity Through modulating fatty acid storage in adipose tissue and secretion of adipokines rosiglitazone significantly enhances insulin sensitivity making it extensively utilized in metabolic and diabetes research particularly type II diabetes studies
Medchemexpress LLC Selenocystamine dih 25g
Selenocystamine dihydrochloride is a selenocysteine derivative that can be used in the synthesis of other active compounds Selenocystamine dihydrochloride can also induce the aggregation of amphiphilic p-sulfonatocalixarene to form supramolecular nanoparticles[1][2][3]
eMolecules 297730-93-9 | 2-(Trifluoromethyl)-3-ethoxydodecafluorohexane | Combi-Blocks | MFCD04038367 | 414.114 | C9H5F15O | 95.000 | CCOC(F)(C(F)(F)C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F | 1g | 335350926
2-(Trifluoromethyl)-3-ethoxydodecafluorohexane | Combi-Blocks | 297730-93-9 | MFCD04038367 | 414.114 | C9H5F15O | 95.000 | CCOC(F)(C(F)(F)C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F | 1g | 335350926
eMolecules 3945-69-5 | 4-(4,6-Dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride | Chem-Impex | MFCD03613550 | 276.720 | C10H17ClN4O3 | 99.000 | [Cl-].COc1nc(OC)nc(n1)[N+]1(C)CCOCC1 | 1kg | 570604846
4-(4,6-Dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride | Chem-Impex | 3945-69-5 | MFCD03613550 | 276.720 | C10H17ClN4O3 | 99.000 | [Cl-].COc1nc(OC)nc(n1)[N+]1(C)CCOCC1 | 1kg | 570604846
Apexbio Technology LLC D4476 301836-43-1 200mg
D4476 (CAS 301836-43-1) is a selective cell-permeable inhibitor of casein kinase 1 (CK1) and ALK5 exhibiting IC50 values of 0 3 M for CK1 and 0 5 M for ALK5 (at 0 1 mM ATP in vitro) It likely acts via ATP-competitive inhibition of CK1 showing minimal to no significant inhibitory activity against SAPK2a/p38 PKB or SGK Treatment with D4476 inhibits CK1-mediated phosphorylation of FOXO1a (Ser322 and Ser325) and RhoB (Ser185) in H4IIE and HeLa cells respectively impacting downstream processes such as nuclear export dynamics and actin cytoskeleton regulation Additionally it induces partial p53-dependent growth arrest in HCT116 cells
Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 5mg, CAS: 130370-60-4.
Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
Medchemexpress LLC Heptadecan-9-amine (9-aminoheptadecane) | 3241-20-1 | MFCD30742905 | 255.48 | C17H37N | 10 G
Heptadecan-9-amine (9-aminoheptadecane) is a long-chain primary alkyl amine commonly used as a linker or building block in organic synthesis and biochemical conjugation. Its C17 spacer provides hydrophobic character useful for creating spacers or modifying solubility in target molecules.
- Primary amine functional group suitable for conjugation reactions.
- Long C17 alkyl chain provides a hydrophobic spacer.
- Useful in linker design and biochemical assay reagent synthesis.
- Available in multiple laboratory package sizes for flexible use.
- Has chemical formula C17H37N, molecular weight 255.48, and CAS 3241-20-1.
Apexbio Technology LLC BMH-21(Synonyms: BMH21, BMH 21, CID 46835406, RNA polymerase I inhibitor BMH-21, RNA Pol I inhibitor BMH-21), 200mg, CAS: 896705-16-1.
BMH-21 (CAS 896705-16-1) is a planar heterocyclic small molecule DNA intercalator that selectively inhibits RNA polymerase I (Pol I)-mediated transcription It preferentially inserts into GC-rich double-stranded DNA regions leading to Pol I blockade and subsequent degradation of its catalytic subunit RPA194 BMH-21 exhibits cytotoxic activity across various human cancer cell lines independently of the p53 status disrupting nucleolar integrity and RNA synthesis Furthermore BMH-21 promotes p53 expression in epithelial compartments of human prostate tissues demonstrating tissue permeability and highlighting its applicability in anticancer research